abstract：:With better understanding of the role of type 2 inflammation in allergic asthma, there has been progress made in the development of new biologic therapies targeting these specific pathways. This review will consider diagnostic criteria for using biologic therapies for pediatric asthma with special emphasis on populati...

journal_title：Pediatric pulmonology

authors： Lovinsky-Desir S

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Asthma is a disease with reversible bronchoconstriction; however, some patients develop fixed airflow obstruction (FAO). Previous studies have reported the incidence and risk factors of FAO in adults; however, the corresponding factors in children remain poorly understood. AIM:To evaluate the incidence and ...

journal_title：Pediatric pulmonology

authors： Sousa AW,Barros Cabral AL,Arruda Martins M,Carvalho CRF

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Disease burden in cystic fibrosis (CF) impacts quality of life, distress, and treatment adherence. The promoting resilience in stress management (PRISM), is a brief patient-focused intervention to promote resilience in adolescents and young adults (AYAs), which may mitigate the negative outcomes, and is prov...

journal_title：Pediatric pulmonology

authors： Toprak D,Nay L,McNamara S,Rosenberg AR,Rosenfeld M,Yi-Frazier JP

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:To report the respiratory function of school-aged children with infantile Pompe disease (IPD) who started enzyme replacement therapy (ERT) in infancy and early childhood. STUDY DESIGN:This is a retrospective chart review of pulmonary function tests of: (a) patients with IPD 5 to 18 years of age, (b) who wer...

journal_title：Pediatric pulmonology

authors： ElMallah MK,Desai AK,Nading EB,DeArmey S,Kravitz RM,Kishnani PS

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Methicillin-resistant Staphylococcus aureus (MRSA) infections in cystic fibrosis (CF) patients have greatly increased in prevalence in the past two decades and may lead to a more rapid rate of lung function decline. The objective of this study was to determine the impact of a MRSA eradication protocol on long...

journal_title：Pediatric pulmonology

authors： Belarski E,Pettit R

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To determine reference values of sniff nasal inspiratory pressure (SNIP) in healthy children. METHODS:This cross-sectional observational study included healthy children aged 6 to 11 years of both sexes. The volunteers underwent a pulmonary function test to rule out respiratory disorders. Respiratory muscle s...

journal_title：Pediatric pulmonology

authors： Marcelino AA,Fregonezi GA,Lira MGA,de Oliveira LM,Araújo PRS,Parreira VF,de Andrade AD,Resqueti V

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Different modalities of noninvasive respiratory support have been recommended for the management of acute bronchiolitis in the pediatric intensive care unit (PICU). High-flow nasal cannula (HFNC) is among the new modalities that have been widely used in the last decade. METHODS:This is a retrospective study...

journal_title：Pediatric pulmonology

authors： Habra B,Janahi IA,Dauleh H,Chandra P,Veten A

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:To develop reference equations of maximal voluntary ventilation (MVV) in children and adolescents, and to test the validity and reproducibility of MVV. STUDY DESIGN:Cross-sectional study. PATIENT-SUBJECT SELECTION:A total of 348 healthy volunteers (6-17 years)-248 for the development of reference equations...

journal_title：Pediatric pulmonology

authors： Silva JC,Carvalho IE,Dal Corso S,Lanza FC

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:To determine the effect of changing electrode positions on vital signs and respiratory effort parameters measured with transcutaneous electromyography of the diaphragm (dEMG) in preterm infants. METHODS:In this observational study, simultaneous dEMG measurements were performed at the standard position and at...

journal_title：Pediatric pulmonology

authors： van Leuteren RW,Bekhuis RE,de Waal CG,de Jongh FH,van Kaam AH,Hutten GJ

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:In cystic fibrosis (CF), the spectrum and frequency of CFTR variants differ by geography and race/ethnicity. CFTR variants in White patients are well-described compared with Latino patients. No studies of CFTR variants have been done in patients with CF in the Dominican Republic or Puerto Rico. METHODS:CFTR...

journal_title：Pediatric pulmonology

authors： Zeiger AM,McGarry ME,Mak ACY,Medina V,Salazar S,Eng C,Liu AK,Oh SS,Nuckton TJ,Jain D,Blackwell TW,Kang HM,Abecasis G,Oñate LC,Seibold MA,Burchard EG,Rodriguez-Santana J

更新日期：2020-02-01 00:00:00

abstract：:Plasminogen deficiency is characterized by fibrin-rich pseudomembrane formation on all mucosal surfaces, particularly the conjunctiva. Respiratory system involvement is common; fibrin often obstructs the upper or lower respiratory tract, causing death. Although many treatments have been applied, no definitive treatmen...

journal_title：Pediatric pulmonology

authors： Kilinc AA,Tarcin G,Kurugoglu S,Schuster V,Cokugras H,Celkan T

更新日期：2020-01-01 00:00:00

abstract：AIM:The aim of this study was to investigate the status and effects of vitamin D supplement as adjuvant therapy in the management of respiratory distress syndrome (RDS) in preterm infants. PATIENT AND METHODS:Vitamin D was prospectively studied in 196 preterm neonates, 96 of them developed RDS, which further subdivide...

journal_title：Pediatric pulmonology

authors： Al-Beltagi M,Rowiesha M,Elmashad A,Elrifaey SM,Elhorany H,Koura HG

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Mesenchymal stromal cell (MSC)-mediated therapeutic effects have been observed in the treatment of lung diseases. For the first time, this treatment was used as rescue therapy in a pediatric patient with a life-threatening respiratory syndrome associated with the filamin A (FLNA) gene mutation. METHODS:A ch...

journal_title：Pediatric pulmonology

authors： Pelizzo G,Avanzini MA,Lenta E,Mantelli M,Croce S,Catenacci L,Acquafredda G,Ferraro AL,Giambanco C,D'Amelio L,Giordano S,Re G,Zennaro F,Calcaterra V

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:A pilot study to compare pulmonary mechanics in a neonatal intensive care unit (NICU) cohort, specifically, comparing lung elastance between male and female infants in the NICU. HYPOTHESIS:Anecdotally, male infants are harder to ventilate than females. We hypothesize that males have higher model-based elast...

journal_title：Pediatric pulmonology

authors： Kim KT,Knopp J,Dixon B,Chase JG

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Telomere length is associated with poorer lung health in older adults, possibly from cumulative risk factor exposure, but data are lacking in pediatric and population-based cohorts. We examined associations of telomere length with lung function in children and mid-life adults. METHODS:Data were drawn from a ...

journal_title：Pediatric pulmonology

authors： Nguyen MT,Saffery R,Burgner D,Lycett K,Vryer R,Grobler A,Dwyer T,Ranganathan S,Wake M

更新日期：2019-12-01 00:00:00

abstract：:Mucus plugging constitutes a nutrient-rich nidus for a bacterial infection that has long been recognized as a potent stimulus for neutrophilic airway inflammation driving progressive lung damage in people with cystic fibrosis (CF). However, mucus plugging and neutrophilic inflammation are already present in many infan...

journal_title：Pediatric pulmonology

authors： Balázs A,Mall MA

更新日期：2019-11-01 00:00:00

abstract：:Neurally adjusted ventilatory assistance (NAVA) can overcome technical difficulties with synchronizing noninvasive ventilation breaths with the patient, a modality often used in very low birthweight infants (VLBW) with apnea of prematurity (AOP). This study is a retrospective single-center investigation into whether N...

journal_title：Pediatric pulmonology

authors： Tabacaru CR,Moores RR Jr,Khoury J,Rozycki HJ

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Bronchopulmonary dysplasia (BPD) is one of the most common complications in premature infants. Since inflammation plays a crucial role in the pathogenesis of BPD, anti-inflammatory drugs, such as corticosteroids, have long been the focus of prevention research. In this meta-analysis, we aim to explore the lo...

journal_title：Pediatric pulmonology

authors： Zheng Y,Xiu W,Lin Y,Ren Y,Zhang B,Yang C

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Patients with bronchopulmonary dysplasia (BPD) may require tracheostomy for long-term mechanical ventilation. Polysomnography (PSG) may predict successful decannulation in children, however it is unclear how this success compares with children without a PSG. To better evaluate this role, we compared decannul...

journal_title：Pediatric pulmonology

authors： Quinlan C,Piccione J,Kim JY,Beck SE,Brooks L,Chandy-Patel R,Escobar E,Afolabi-Brown O

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Our objective was to determine those characteristics associated with reversibility of airflow obstruction and response to maximal bronchodilation in children with severe asthma through the Severe Asthma Research Program (SARP). METHODS:We performed a cross-sectional analysis evaluating children ages 6 to 17...

journal_title：Pediatric pulmonology

authors： Coverstone AM,Bacharier LB,Wilson BS,Fitzpatrick AM,Teague WG,Phipatanakul W,Wenzel SE,Gaston BM,Bleecker ER,Moore WC,Ramratnam S,Jarjour NN,Ly NP,Fahy JV,Mauger DT,Schechtman KB,Yin-DeClue H,Boomer JS,Castro M

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:While pulmonary arterial hypertension (PAH) is rare in infants and children, it results in substantial morbidity and mortality. In recent years, prognosis has improved, coinciding with the introduction of new PAH-targeted therapies, although much of their use in children is off-label. Evidence to guide the tr...

journal_title：Pediatric pulmonology

authors： Beghetti M,Gorenflo M,Ivy DD,Moledina S,Bonnet D

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Exercise ventilation efficiency index in cardiopulmonary exercise testing (CPET) is elevated in patients with heart failure providing useful information on disease progression and prognosis. Few data, however, exist for ventilation efficiency index among cystic fibrosis (CF) patients. AIMS:To assess venti...

journal_title：Pediatric pulmonology

authors： Kampouras A,Hatziagorou E,Avramidou V,Georgopoulou V,Kirvassilis F,Hebestreit H,Tsanakas J

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:To assess whether children with sleep-disordered breathing (SDB) symptom severity above a certain level, measured by a validated questionnaire, improve after adenotonsillectomy (AT) compared to no intervention. METHODS:Children with snoring and tonsillar hypertrophy (4 to 10-years old), who were candidates f...

journal_title：Pediatric pulmonology

authors： Papadakis CE,Chaidas K,Chimona TS,Zisoglou M,Ladias A,Proimos EK,Miligkos M,Kaditis AG

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:While the impact of fertility treatments on the perinatal outcome is well established, the long-term effects on offspring are yet to be determined. The current study aimed to investigate the risk of long-term obstructive sleep apnea (OSA) among children born following in vitro fertilization (IVF) and ovulatio...

journal_title：Pediatric pulmonology

authors： Imterat M,Wainstock T,Sheiner E,Landau D,Walfisch A,Harlev A

更新日期：2019-10-01 00:00:00

abstract：:Tracheal bronchus (TRB) has been generally considered an anatomical variant of the tracheobronchial tree without a precise pathological effect. Its prevalence is estimated to be between 0.2% to 3% of all children undergoing bronchoscopy and scientific information has been limited to case reports or small case series. ...

journal_title：Pediatric pulmonology

authors： Moreno M,Castillo-Corullón S,Pérez-Ruiz E,Luna MC,Antón-Pacheco JL,Mondejar-Lopez P,De-la-Serna O,Villa JR,Osona B,Torres-Borrego J,Santiago-Burruchaga M,Asensio O,Andres-Martin A,Delgado-Pecellin I,González Y,Palmero A,E

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Ivacaftor is a significant innovation in the treatment of cystic fibrosis (CF) with gating mutations. A substantial percentage of patients with CF have severe lung involvement, but these patients are usually excluded from phase III clinical trials. Thus, the effectiveness of ivacaftor in this population has ...

journal_title：Pediatric pulmonology

authors： Salvatore D,Carnovale V,Iacotucci P,Braggion C,Castellani C,Cimino G,Colangelo C,Francalanci M,Leonetti G,Lucidi V,Manca A,Vitullo P,Ferrara N

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:Among older children, sleep-disordered breathing (SDB) is associated with measurable neurocognitive consequences. However, diagnostic SDB thresholds are lacking for infants < 12 months. We sought to evaluate the relationship between SDB indices, gestational age (GA), and postmenstrual age (PMA) for infants wh...

journal_title：Pediatric pulmonology

authors： Matlen LB,Hassan F,Shellhaas RA

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:We sought to compare gas exchange, respiratory mechanics, and asynchronies during pressure support ventilation (PSV), sigh adjunct to PSV (PSV SIGH), and neurally adjusted ventilatory assist (NAVA) in hypoxemic infants after cardiac surgery. DESIGN:Prospective, single-center, crossover, randomized physiolog...

journal_title：Pediatric pulmonology

authors： Bonacina D,Bronco A,Nacoti M,Ferrari F,Fazzi F,Bonanomi E,Bellani G

更新日期：2019-07-01 00:00:00

abstract：AIM:Our aim was to evaluate the correlation of Adenosine monophosphate challenge test (AMP-PCW) results with the patients' subsequent clinical course. METHODS:We performed a 6-year retrospective cohort study of young children with suspected asthma who underwent AMP-PCW test. RESULTS:Fifty four children were included ...

journal_title：Pediatric pulmonology

authors： Levin G,Rottensctreich A,Picard E,Avital A,Springer C,Cohen S

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Cystic fibrosis (CF) genotyping has garnered increased attention since the discovery of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in 1989 led to the identification of over 1700 mutations on chromosome 7. Yet, little is known about the genetic profile of CF patients in Turkey. This s...

journal_title：Pediatric pulmonology

authors： Atag E,Bas Ikizoglu N,Ergenekon AP,Gokdemir Y,Eralp EE,Ata P,Ersu R,Karakoc F,Karadag B

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:To identify the spirometric equations that are most appropriate for use in children and adolescents living in Bogota, Colombia after evaluating a set of relevant previously-developed equations, including the Global Lung Function Initiative (GLI) 2012 spirometry reference equations. METHODS:Healthy children ...

journal_title：Pediatric pulmonology

authors： Aristizabal-Duque R,Castiblanco E,Rodriguez I,Sossa-Briceño MP,Rodriguez-Martinez CE

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and endoscopic ultrasound with an echobronchoscope-guided fine needle aspiration (EUS-B-FNA) are useful modalities in the evaluation of mediastinal pathologies in adults. However, sparse data are available in children. OBJECTIVE:To...

journal_title：Pediatric pulmonology

authors： Gulla KM,Gunathilaka G,Jat KR,Sankar J,Karan M,Lodha R,Kabra SK

更新日期：2019-06-01 00:00:00

abstract：RATIONALE:Increasing evidence suggests the forced oscillation technique (FOT) has the capacity to provide non-invasive monitoring and diagnosis of respiratory disease in young children. However, which FOT outcomes provide the most pertinent clinical information is currently unknown. The aim of this study was to determi...

journal_title：Pediatric pulmonology

authors： Evans DJ,Schultz A,Verheggen M,Hall GL,Simpson SJ

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Decreased lung function is common in preterm-born survivors. Increased fractional exhaled nitric oxide (FeNO) appears to be a reliable test for eosinophillic airway inflammation especially in asthma. We, systematically, reviewed the literature to compare FeNO levels in preterm-born children and adults who di...

journal_title：Pediatric pulmonology

authors： Course CW,Kotecha S,Kotecha SJ

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Magnetic Resonance Imaging (MRI) techniques to image the larynx have evolved rapidly into a promising and safe imaging modality, without need for sedation or ionizing radiation. MRI is therefore of great interest to image pediatric laryngeal diseases. Our aim was to review MRI developments relevant for the p...

journal_title：Pediatric pulmonology

authors： Elders BBLJ,Hermelijn SM,Tiddens HAWM,Pullens B,Wielopolski PA,Ciet P

更新日期：2019-04-01 00:00:00

abstract：AIM:Children with respiratory conditions benefit from care provided by pediatric pulmonologists. As these physicians are a small portion of the overall pediatric workforce, it is necessary to understand the practices and career plans of these specialists. METHODS:An internet survey was developed by the American Academ...

journal_title：Pediatric pulmonology

authors： Harris C,Katkin J,Cataletto M,Dorkin H,Laskosz L,Ruch-Ross H

更新日期：2019-04-01 00:00:00

abstract：INTRODUCTION:In moderate-severe asthma exacerbation, salbutamol by inhaler (MDI) is superior to salbutamol delivered by nebulizer (NEB); however, to our knowledge, no studies in children with exclusively severe exacerbations were performed. OBJECTIVE:To compare the efficacy of salbutamol and ipratropium bromide by MDI...

journal_title：Pediatric pulmonology

authors： Iramain R,Castro-Rodriguez JA,Jara A,Cardozo L,Bogado N,Morinigo R,De Jesús R

更新日期：2019-04-01 00:00:00

abstract：:Intrauterine inflammation generates inflammatory mediators that damage the developing bronchoalveolar epithelium, resulting in neonatal lung injury. Lung fluid transport disorders are the main reasons for the development of pulmonary edema, an important pathology of lung injury. Previous studies suggested that epithel...

journal_title：Pediatric pulmonology

authors： Lu K,Chen X,Zhu W,Mao X,Yang Y,Qiu J,Zhang M,Cheng R

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:We sought to describe the phenotype for patients with P.I.G. including presentation, evaluation, cardiac co-morbidities, high resolution computed tomography findings, and outcomes. METHODS:With institutional review board approval, we performed a retrospective review of patients with biopsy-proven P.I.G. Bio...

journal_title：Pediatric pulmonology

authors： Liptzin DR,Baker CD,Darst JR,Weinman JP,Dishop MK,Galambos C,Brinton JT,Deterding RR

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Most international asthma guidelines recommend that children ≤5 years with asthma or recurrent wheezing be treated with daily low- moderate dose inhaled corticosteroids (ICS) as the preferred controller and leukotriene receptor antagonists (LTRA) as alternative therapy. There is no systematic review comparin...

journal_title：Pediatric pulmonology

authors： Castro-Rodriguez JA,Rodriguez-Martinez CE,Ducharme FM

更新日期：2018-12-01 00:00:00